Letter | Published:

Radiation Lethality and Local Tissue Damage in Histamine-depleted Rats

Nature volume 180, page 1467 (28 December 1957) | Download Citation

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Abstract

THE liberation of histamine from cells damaged by ionizing radiations is considered to play an important part in certain radiation changes, particularly in skin erythema and in certain aspects of the acute radiation syndrome1. While some elevation of plasma histamine is said to occur after total-body irradiation2, estimations of tissue histamine following irradiation have been reported unchanged3 or lowered4. The administration of histamine at the time of irradiation, to animals subjected to lethal doses of total-body irradiation, has been found to afford a weak but variable protective effect5.

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References

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    , , and , J. Physiol., 133, 506 (1956).

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    , and , quoted by Bacq, Z. M., and Alexander, P., in “Fundamentals of Radiobiology” (Butterworths Scientific Publications, London, 1955).

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    , and , J. Physiol., 109, 190 (1949).

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    , and , J. Physiol., 120, 550 (1953).

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    , and , J. Path. Bact., 69, 269 (1955).

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Affiliations

  1. Radiobiological Research Unit, Cancer Institute Board, Victoria, Australia.

    • H. A. S. VAN DEN BRENK

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https://doi.org/10.1038/1801467a0

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