Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Toxicity of Erythromycin

Abstract

IN the course of studies on antibiotic therapy of rickettsial infection in the guinea pig, it was found that oxytetracycline, chlortetracycline and tetracycline administered intramuscularly were tolerated well in the dosages employed. The administration of erythromycin on an equivalent dose-weight basis, however, resulted in death of a portion of the test animals. The picture observed was comparable to that noted by Kaipainen and Faine1 following oral, intraperitoneal or intravenous administration of the drug. Because the response of the guinea pig to erythromycin appears to differ from a simple toxicity phenomenon, the following observations are reported.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kaipainen, W. J., and Faine, S., Nature, 174, 969 (1954).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

TIGERTT, W., GOCHENOUR, W. Toxicity of Erythromycin. Nature 180, 1429–1430 (1957). https://doi.org/10.1038/1801429b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1801429b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing