IN the course of studies on antibiotic therapy of rickettsial infection in the guinea pig, it was found that oxytetracycline, chlortetracycline and tetracycline administered intramuscularly were tolerated well in the dosages employed. The administration of erythromycin on an equivalent dose-weight basis, however, resulted in death of a portion of the test animals. The picture observed was comparable to that noted by Kaipainen and Faine1 following oral, intraperitoneal or intravenous administration of the drug. Because the response of the guinea pig to erythromycin appears to differ from a simple toxicity phenomenon, the following observations are reported.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Kaipainen, W. J., and Faine, S., Nature, 174, 969 (1954).
Rights and permissions
About this article
Cite this article
TIGERTT, W., GOCHENOUR, W. Toxicity of Erythromycin. Nature 180, 1429–1430 (1957). https://doi.org/10.1038/1801429b0
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.