Letter | Published:

Chemical Nature of Parathyroid Hormone

Nature volume 180, page 1429 (21 December 1957) | Download Citation

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Abstract

MOST of the data accumulated in the past thirty-two years1 has led to the conclusion that parathyroid hormone is a protein. In 1954, Handler, Cohn and Dratz2 attempted to purify this hormone by means of ion-exchange chromatography, but found hormonal activity associated with a number of protein peaks. On the basis of their results, they suggested that the hormonal activity might reside in a smaller molecule, presumably not necessarily nitrogenous, which readily absorbs on proteins. Raoul, Mornay and Prelot3 have recently claimed to have prepared, by two different lipid extraction methods, a highly active material which did not contain nitrogen. On the basis of unreported evidence, they suggested that this active substance was steroidal in nature. Since the D vitamins, which are steroid, closely mimic, in some respects, the action of parathyroid hormone on bone and kidney, the possibility that this hormone is a steroid merits consideration.

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References

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    , Chapter 7 in Pincus, G., and Thimann, K. U., “The Hormones”, 1 (Academic Press, Inc., New York, 1948). , and , Chapter 4 in Pincus, G., and Thimann, K. U., “The Hormones”, 3 (Academic Press, Inc., New York, 1955).

  2. 2.

    , , and , in “Metabolic Interrelations with Special Reference to Calcium”, trans. 5th Josiah Macy Conf., 320 (Progress Associated, Inc., New York, 1954).

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    , , and , C.R. Acad. Sci., Paris, 240, 1151 (1955).

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    , , and , J. Biol. Chem., 168, 167 (1947).

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    , , and , J. Physiol., 125, 383 (1954).

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    , Quart. J. Pharm. Pharmacol., 8, 197 (1935).

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Author notes

    • HOWARD RASMUSSEN

    Present address: Rockefeller Institute for Medical Research, New York City.

Affiliations

  1. Medical Unit, University College Hospital Medical School, London, W.C.1.

    • HOWARD RASMUSSEN
    •  & ROLAND WESTALL

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https://doi.org/10.1038/1801429a0

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