Letter | Published:

Antimitotic Activity of 5-Tertiary Butyl Benzimidazolone

Nature volume 180, pages 14281429 (21 December 1957) | Download Citation



IN chronic toxicity tests of several derivatives of benzimidazolone, the 5-substituted compounds were well tolerated, with the exception of the 5-tertiary butyl benzimidazolone. This substance caused retardation of growth in rats receiving the standard dose of 500 mgm./kgm./day by stomach tube, with death after 20–25 days of treatment. Hæmatological examination after the onset of the loss in weight revealed a severe anæmia and leukopænia, found at autopsy to be the results of aplasia of the bone marrow. Lymphoid atrophy was also seen; but other tissues showed no change, except for the presence in various organs of large numbers of mitotic figures.

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    • J. E. HAWKINS JUN.

    Present address: Department of Otolaryngology, New York University—Bellevue Medical Center, New York 16.


  1. Merck Institute for Therapeutic Research, Rahway, New Jersey.

    • H. C. STOERK
    • , R. N. ARISON
    •  & J. E. HAWKINS JUN.


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