IN chronic toxicity tests of several derivatives of benzimidazolone, the 5-substituted compounds were well tolerated, with the exception of the 5-tertiary butyl benzimidazolone. This substance caused retardation of growth in rats receiving the standard dose of 500 mgm./kgm./day by stomach tube, with death after 20–25 days of treatment. Hæmatological examination after the onset of the loss in weight revealed a severe anæmia and leukopænia, found at autopsy to be the results of aplasia of the bone marrow. Lymphoid atrophy was also seen; but other tissues showed no change, except for the presence in various organs of large numbers of mitotic figures.
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STOERK, H., ARISON, R. & HAWKINS, J. Antimitotic Activity of 5-Tertiary Butyl Benzimidazolone. Nature 180, 1428–1429 (1957). https://doi.org/10.1038/1801428a0
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