Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Sensitization by Œstradiol to the Production of Experimental Nephrocalcinosis


EARLIER experiments showed that excessive oral administration of mono- or dibasic-phosphates produces nephrocalcinosis in the rat, and that these renal lesions are aggravated by mineralocorticoids, such as deoxycorticosterone1–3. Recent experiments revealed that, under similar experimental conditions, the nephrocalcinosis produced by oral administration of acid sodium phosphate is not aggravated by methyltestosterone, progesterone, corticosterone, Δ1-cortisol acetate, or Δ1-cortisone acetate, but curiously, œstradiol proved to be even more effective in this respect than deoxycorticosterone. It has long been known that folliculoid or ‘œstrogenic’ hormones exert a pronounced effect on calcium metabolism in birds, presumably because in the avian species the production of calcified egg shells is closely related to the action of sex hormones. In mammals, on the other hand, folliculoids do not exert any comparably pronounced effect upon calcium metabolism, and, therefore, the production of intense nephrocalcinosis by œstradiol (when given in combination with phosphates) was made the subject of a special study.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout


  1. Friedman, S. M., Friedman, C. L., and Polley, J. R., Amer. J. Physiol., 153, 226 (1948).

    PubMed  CAS  Google Scholar 

  2. Selye, H., and Bois, P., Acta Endocrinol., 22, 330 (1956).

    Article  CAS  Google Scholar 

  3. Selye, H., Mintzberg, J., and Rowley, E. M., J. Pharmacol. and Exp. Therap., 85, 42 (1945).

    CAS  Google Scholar 

  4. Selye, H., Rev. Canad. Biol., 1, 577 (1942).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

SELYE, H. Sensitization by Œstradiol to the Production of Experimental Nephrocalcinosis. Nature 180, 1420–1421 (1957).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing