Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Induction of Mouse Leukæmia with Purified Nucleic Acid Preparations

Abstract

RECENT studies by Gross1 and others2,3 have shown that leukæmia with immunogenetic characteristics of the recipient strain can be induced in certain low-leukæmia-incidence strains of mice by injecting into newborn animals cell-free extracts of tissues of certain high-leukæmia strains. Although the active leukæmogenic agent has been referred to as a virus, direct evidence on this point has been lacking. At present it can be said only that the agent is filtrable and thermolabile, and is transmitted in certain families of mice from one generation to another directly through the embryos. Under certain poorly defined conditions, cell-free extracts of leukæmic organs may also produce parotid gland tumours, sarcomas and perhaps other neoplasms, indicating that the active agent is either multipotent or that extracts contain several oncogenic agents.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Gross, L., Proc. Soc. Exp. Biol. and Med., 76, 27 (1951).

    Article  CAS  Google Scholar 

  2. Furth, J., Buffett, R., Banasiewicz-Rodriguez, M., and Upton, A. C., Proc. Soc. Exp. Biol. and Med., 93, 165 (1956).

    Article  CAS  Google Scholar 

  3. Stewart, S. E., J. Nat. Cancer Inst., 16, 41 (1955).

    PubMed  CAS  Google Scholar 

  4. Ephrussi-Taylor, H., “A Symposium on the Chemical Basis of Heredity” (edit. McElroy, W. D., and Glass, B., 299–320 (The Johns Hopkins Press, Baltimore, 1957).

    Google Scholar 

  5. Sreenivasaya, M., and Pirie, N. W., Biochem. J., 32, 1707 (1938).

    Article  CAS  Google Scholar 

  6. Mayers, V. L., and Spizigen, F., J. Biol. Chem., 210, 877 (1954).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

HAYS, E., SIMMONS, N. & BECK, W. Induction of Mouse Leukæmia with Purified Nucleic Acid Preparations. Nature 180, 1419–1420 (1957). https://doi.org/10.1038/1801419b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1801419b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing