Letter | Published:

Ineffectiveness of Selenium in the Treatment of Nutritional Muscular Dystrophy in the Rabbit

Nature volume 180, page 1419 (21 December 1957) | Download Citation



IT has been found recently that selenium is effective in the prevention of two experimental syndromes induced by feeding a vitamin E-deficient diet. These are exudative diathesis in the chick (Stokstad, E. L. R., private communication) and necrotic liver degeneration in the rat1. Factor III, an unidentified substance in addition to vitamin E and cystine having protective activity against liver necrosis, has been identified as selenium. These reports pose the question whether selenium may have tocopherol-replacing properties with respect to muscular dystrophy, the classical symptom of vitamin E deficiency in the young of most species.

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  1. 1.

    , and , J. Amer. Chem. Soc., 79, 3292 (1957).

  2. 2.

    , Proc. Soc. Exp. Biol. and Med., 74, 148 (1950).

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  1. Division of Animal Nutrition, University of Illinois, Urbana.

    • H. H. DRAPER


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