Letter | Published:

Elastin, a Metabolically Active Lipoprotein

Naturevolume 180pages13601361 (1957) | Download Citation

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Abstract

THE protein elastin has been generally regarded as an inert substance on the basis of its solubility properties1 and tracer studies2 employing carbon-14. That elastic tissue demonstrates dynamic, functional properties other than that of elasticity has been suggested in part by studies on arteriosclerotics. The breakdown of the arterial elastic lamellæ is generally reported to be the initial event in the pathological changes of the arteries3. That the elastic lamellæ of arteries act as selective filters to tissue fluid components has been proposed4. The present report demonstrates that elastin, as it exists in situ in elastic tissue, is composed of metabolically active components.

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References

  1. 1

    Stein, W. H., and Miller, E. C., jun. J. Biol. Chem. 125, 599 (1938).

  2. 2

    Slack, H. G. B., Nature, 174, 512 (1954).

  3. 3

    Blumenthal, H. J., et al., Amer. J. Path., 26, 989 (1950).

  4. 4

    Gross, J., Symposium on Atherosclerosis, Nat. Res. Coun., Washington, p. 41 (1954).

  5. 5

    Findlay, G. H., Brit. J. Dermat., 66, 16 (1954).

  6. 6

    Laszlo, J., and Schuler, D., Acta Physiol. Acad. Sci. Hung., 6, 463 (1954).

  7. 7

    Lansing, A. I., Trans. Macy Conf. on Connective Tissue, 2, 45 (1951).

  8. 8

    Rapport, M. M., and Franzl, R. E., J. Biol. Chem., 225, 851 (1957).

  9. 9

    Partridge, S. M., and Davis, H. F., Biochem. J., 61, 21 (1955).

  10. 10

    Banga, I., and Balo, J., Acta Physiol. Acad. Sci. Hung., 6, 235 (1954).

  11. 11

    Kendall, F. E., J. Biol. Chem., 138, 97 (1941).

  12. 12

    Boucek, R. J., and Noble, N. L., Circ. Res., 5, 27 (1957).

  13. 13

    Menschik, Z., Anat. Rec., 124, 333 (1956).

  14. 14

    Sinclair, H. M., Lancet, i, 386 (1956).

  15. 15

    Rhinehart, J. F., “Connective Tissue in Health and Disease”, edit. Asboe-Hansen G., p. 239 (Munksgaard, Copenhagen, 1954).

  16. 16

    Peifer, J. J., Fed. Proc., 16, 232 (1957).

  17. 17

    Johnson, R. M., and Albert, S., J. Biol. Chem., 200, 335 (1953).

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Affiliations

  1. Department of Physiology, Division of Basic Health Sciences, Emory University, Georgia

    • FRANK S. LABELLA

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https://doi.org/10.1038/1801360a0

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