Letter | Published:

Action of Ethylene Dibromide on Hen Gonadotrophic Hormones

Nature volume 180, pages 13581359 (14 December 1957) | Download Citation



ETHYLENE dibromide (dibromoethane) was found to remain in small amounts in fumigated grain up to six weeks after fumigation1. This fact, unusual for fumigants, had a harmful effect on laying hens. Diminution in size of egg, followed by cessation of laying were observed. Significant decrease in weight of egg occurred even when grain containing 15 p.p.m. of ethylene dibromide was fed to laying hens over 12 weeks2. The total amounts of ethylene dibromide ingested by such hens were well below those reported as harmless to various laboratory animals3,4. The following observations lead to the hypothesis that the action of small amounts of ethylene dibromide is very specific on pituitary gonadotrophic hormones and should be distinguished from the general poisonous action of large doses.

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  1. 1.

    , and , J. Sci. Food and Agric., 6, 592 (1955).

  2. 2.

    , , and , J. Sci. Food and Agric., 6, 600 (1955).

  3. 3.

    , , , and , Ann. App. Biol., 33, 389 (1946).

  4. 4.

    , , , , and , Arch. Ind. Hyg. Occup. Med., 6, 158 (1952).

  5. 5.

    , , and , Proc. Soc. Exp. Biol. Med., 85, 393 (1954).

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  1. Department of Animal Nutrition, Agricultural Research Station, Rehovot, Israel.



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