Letter | Published:

Action of Glucose-I-Phosphate on the Deposition of Phosphate in the Bones of Growing Diabetic Rats

Naturevolume 180pages13571358 (1957) | Download Citation



IT has been shown in a previous paper1 that the ossification process of growing diabetic rats is strongly retarded in comparison with normal animals and that the administration of insulin restores the ossification process to a normal rate. An even more pronounced effect was obtained by daily injections of 1–2 gm./kgm. of glucose-1-phosphate over a period of 10–15 days. The ready response to glucose-1-phosphate suggested that the impairment of ossification in diabetes might be attributed to a possible glucose-1-phosphate deficiency and that this ester might act as phosphate carrier or donor in phosphate deposition in the bones.

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  1. 1

    De Bastiani, G., and Petrelli, F., Boll. Soc. Eustachiana dell'Universita di Camerino (in the press).

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  1. Institutes of Biological Chemistry and of Physiology, University of Camerino and Institute of Pharmacology, University of Rome

    • , G. DE BASTIANI
    • , F. PETRELLI
    •  & B. FISCHETTI


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