Letter | Published:

Anion Exchange Chromatography and Molecular Size of Deoxyribonucleic Acid

Naturevolume 180pages13551356 (1957) | Download Citation



IN conjunction with investigations on deoxyribonucleic acid isolated from white blood cells of patients with leukæmia (Polli, E. E., Rosoff, M., di Mayorca, G., and Cavalieri, L. F. (unpublished) and ref. 1), an interesting correlation was found between the molecular parameters of the acid and their chromatographic profiles obtained by fractionation on columns of ‘Ecteola’2.

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  1. 1

    Polli, E. E., and Semenza, S., Biochem. Z., 327, 231 (1955).

  2. 2

    Bendich, A., Fresco, J. R., Rosenkranz, H. S., and Beiser, S. M., J. Amer. Chem. Soc., 77, 3671 (1955). Bendich, A., Pahl, H. B., and Beiser, S. M., Cold Spring Harbor Symp. Quant. Biol., 21, 31. (1956).

  3. 3

    Kay, E. R. M., Simmons, N. W., and Dounce, A. L., J. Amer. Chem., Soc., 74, 1724 (1952).

  4. 4

    Chargaff, E., Lipshitz, R., Green, C., Hodes, M. E., J. Biol. Chem., 192, 223 (1951).

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    Eisenberg, A., and Frei, E. H., J. Polymer Sci., 14, 417 (1954).

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    Shooter, K. V., and Butler, J. A. V., J. Polymer Sci., 23, 705 (1957); Trans. Farad. Soc., 52, 734 (1956).

  7. 7

    Oth, A., Conférences et Rapports P. 142, 3ème Congrès International de Biochimie, Bruxelles (1955).

  8. 8

    Bendlich, A., Pahl, H. B., Rosenkranz, H. S., and Rosoff, M., Soc. Exp. Biol. Symp., 12, Sept. 16–20, 1957 (in the press).

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  1. Laboratories of the Sloan–Kettering Division, Cornell University Medical College, New York, 21



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