Abstract
THE blood glucose concentration decreases very rapidly during incubation of a sample of blood in vitro at 37° C.1–3. During this glycolytic process very substantial changes take place in the content of the organic phosphate esters. These changes are related to the decrease of blood glucose, as was suggested by Paysant and Wolf3. Many workers have studied the behaviour of the acid-soluble phosphorus fractions in blood during incubation in vitro, and they have observed an increase of inorganic phosphate, a decrease of easily hydrolysable phosphate esters (this fraction represents the phosphorus largely derived from, adenosine triphosphate), a decrease of phosphate fraction hydrolysable with difficulty (phosphorus released largely from hexose phosphates) and a decrease of non-hydrolysable phosphate esters (this fraction consists mainly of the 2,3-diphosphoglycerate)3–5.
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References
Cantarow, A., and Trumper, M., “Clinical Biochemistry” (Philadelphia, 1949).
Macho, L., Clin. Chim. Acta (in the press).
Paysant, P., and Wolf, R., C.R. Soc. Biol., 146, 1250 (1952).
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Macho, L., Chemické Zvesti, 11, 175 (1957).
Rohdewald, M., and Weber, M., Hoppe-Seyler's Z. Physiol. Chemie, 306, 95 (1957).
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MACHO, L. Changes of Organic Phosphate Esters during Glycolysis in Blood followed by a Paper Chromatography Method. Nature 180, 1351–1352 (1957). https://doi.org/10.1038/1801351a0
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DOI: https://doi.org/10.1038/1801351a0
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