Letter | Published:

Mucopolysaccharides from Cartilage and Nucleus Pulposus

Nature volume 180, pages 13411342 (14 December 1957) | Download Citation

Subjects

Abstract

Meyer and Rapport1 described the isolation from hyaline cartilage of two chondroitin sulphates, A and C. The only differences so far reported2 between these are in the specific optical rotation and alcohol solubility of their calcium, salts. Orr3 found that chondroitin sulphate from cartilage gives an infra-red spectrum which suggests that the product is a mixture of two isomers, A and B (see below). By counter-current electrophoresis he was able to obtain the faster component of this mixture, which exhibited in the 700–1,000 cm.−1 region 3 bands, at 928, 855 and 725 cm.−1, respectively, and was called the A isomer. The B isomer, on the other hand, was isolated alone in a well-defined form from the nucleus pulposus and showed two bands at 825 and 775 cm.−1, respectively. Meyer et al.2 pointed out the similarity between Orr's B isomer and chondroitin sulphate C. On the other hand, both A types show the same optical rotation and origin. The following results seem to give a different picture of the mucopolysaccharides of cartilage and nucleus pulposus.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , and , Science, 113, 596 (1951).

  2. 2.

    , , , and , Biochim. Biophys. Acta, 21, 506 (1956).

  3. 3.

    , Biochim. Biophys. Acta, 14, 173 (1954).

  4. 4.

    , and , J. Biol. Chem., 185, 725 (1950).

  5. 5.

    , , and , Experientia (in the press).

  6. 6.

    , and , J. Biol. Chem., 191, 591 (1951).

  7. 7.

    , and , J. Biol. Chem., 211, 565 (1954).

  8. 8.

    , , , , and , Nature, 179, 1078 (1957).

Download references

Author information

Author notes

    • G. BERNARDI

    Present address: National Research Council, Division of Applied Biology, Ottawa, Canada.

Affiliations

  1. Department of Textile Industries, Institute of Technology, Bradford.

    • G. BERNARDI
    •  & F. HAPPEY
  2. Royal Infirmary, Bradford.

    • A. NAYLOR

Authors

  1. Search for G. BERNARDI in:

  2. Search for F. HAPPEY in:

  3. Search for A. NAYLOR in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/1801341a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.