Letter | Published:

Isotopic Tracer Method for measurement of Iron Lost into and re-absorbed from Gastro-intestinal Bleeding Lesions

Naturevolume 180pages12781279 (1957) | Download Citation



IT has been shown1,2, with the help of rabbit and sheep erythrocytes labelled with iron-59, that appreciable amounts of iron from hæmoglobin were absorbed when these cells were administered orally to human beings. So far as we know, no information is available on the re-absorption of hæm-attached iron from intestinal bleeding lesions. A method for measuring such a re-absorption is here proposed.

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    Callender, S. T., Mallett, B. J., and Smith, M. D., Brit. J. Hæmatol., 3, 186 (1957).

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    Walsh, R. J., Kaldor, I., Brading, I., and George, E. P., Aust. Ann. Med., 4, 272 (1955) (cited by Callender, ref. 1).

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    Sterling, K., and Gray, S. J., J. Clin. Invest., 29, 1614 (1950).

  4. 4

    Roche, M., Perez-Gimenez, M. E., Layrisse, M., and Di Prisco, E., J. Clin. Invest. (July 1957).

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    Hine, G. J., Burrows, B. A., Apt, L., Pollycove, M., Ross, J. F., and Sarkes, L. A., Nucleonics, 13, 23 (1955).

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    Bernhart, F. W., and Skeggs, L., J. Biol. Chem., 147, 19 (1943).

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    Owen, jun., C. A., Bollman, J. L., and Grindlay, J. H., J. Lab. and Clin. Med., 44, 238 (1954).

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    Moore, C. V., and Dubach, R., in “Modern Trends in Blood Disease” (Butterworth and Co., Ltd.. London, 1955).

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  1. Instituto de Investigaciones Médicas, Fundación Luis Roche, Plaza Morelos, Caracas, Venezuela

    • M. ROCHE
    •  & A. LEVY


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