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Biosynthesis of γ-Guanidinobutyric Acid from γ-Aminobutyric Acid and Arginine

Nature volume 180, pages 1125–1126 (1957)Cite this article

Abstract

THE recent discovery by Irreverre et al.1,2 of γ-guanidinobutyric acid in mammalian brain and other tissues stimulated research on its biosynthesis and physiological role. Thoai et al.3 have shown that in many invertebrates γ-guanidinobutyric acid is synthesized by the oxidation of arginine through the action of L-amino-acid oxidase. The present communication shows that in mammals it is synthesized by a transamidination reaction4 involving γ-aminobutyric acid and an amidine donor such as arginine.

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References

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Authors and Affiliations

  1. Laboratory of Clinical Biochemistry, National Heart Institute, National Institutes of Health, Bethesda, Maryland

    JOHN J. PISANO, CHOZO MITOMA & SIDNEY UDENFRIEND

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  1. JOHN J. PISANO
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  2. CHOZO MITOMA
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  3. SIDNEY UDENFRIEND
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PISANO, J., MITOMA, C. & UDENFRIEND, S. Biosynthesis of γ-Guanidinobutyric Acid from γ-Aminobutyric Acid and Arginine. Nature 180, 1125–1126 (1957). https://doi.org/10.1038/1801125a0

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