Abstract
THE penetration of ribonuclease into ascites tumour and bone marrow cells has been described elsewhere1. It was shown that the biochemical effects induced in different types of cells by the enzyme seems to depend on the original level of ribonuclease in these cells. Landschütz ascites tumour cells, which are very poor in ribonuclease as compared with bone marrow cells, are very much more sensitive to its action1,2. These observations, together with the fact that the bone marrow cells, although they are richer in ribonuclease, are poorer in ribonucleic acid, have led us to determine the normal level of ribonuclease in different organs of normal animals, and to attempt to find if there is a relationship between the content of ribonuclease and that of ribonucleic acid in normal and cancerous tissues.
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LEDOUX, L., PILERI, A., VANDERHAEGHE, F. et al. Relation between Ribonuclease Activity and Ribonucleic Acid Content. Nature 180, 1048–1049 (1957). https://doi.org/10.1038/1801048b0
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DOI: https://doi.org/10.1038/1801048b0
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