Plethysmometric Measurement of Swelling in the Feet of Small Laboratory Animals


VARIOUS authors have described phlethysmometric1–3 and planimetric4–6 methods of measuring the volume of rats' and guinea pigs' feet before and after the injection of irritant substances. Such methods have formed the basis for the determination of the anti-inflammatory activity of adrenal steroids and other agents, and for the measurement of the local response to injections of histamine and histamine-releasing agents.

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  1. 1

    Domenjoz, R. D., Internat. Rec. Med., 165, 467 (1952).

  2. 2

    Wilhelmi, G., and Domenjoz, R. D., Arzneimittelforschung, 1, 151 (1951).

  3. 3

    Domenjoz, R. D., Schweiz. Med. Woch., 40, 1023 (1952).

  4. 4

    Ungar, G., Damgaard, E., and Weinstein, H. G., Amer. J. Physiol., 166, 340 (1951).

  5. 5

    French, C. E., Allen, J. R., and Davis, K. J., Proc. Soc. Exp. Biol. and Med., 89, 41 (1955).

  6. 6

    Winter, C. A., Hollings, H. L., and Stebbins, R. B., Endocrinol., 52, 123 (1953).

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BUTTLE, G., D'ARCY, P., HOWARD, E. et al. Plethysmometric Measurement of Swelling in the Feet of Small Laboratory Animals. Nature 179, 629 (1957).

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