Acylacrylic Acids and Biological Activity


IT has recently been reported1 that β-acetylacrylic acid and its (ethyl) ester are rather poisonous to mice, about 1 mgm. given subcutaneously to a 25-gm. mouse being lethal. There was also an increase in leucocytes, which in the case of the ester appear after about three weeks and in the case of the acid after a few hours. In the latter case the effect disappeared after about a day and this increase was assumed to be due to acidosis. This has now been found to be almost certain, because injection of a neutralized solution caused no clear rapid increase followed by a rapid decrease in leucocytes. However, the poisonous effect with neutralized acid remained almost unchanged, 2 mgm. being lethal.

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HELLSTRÖM, N. Acylacrylic Acids and Biological Activity. Nature 179, 589–590 (1957) doi:10.1038/179589b0

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