Effect of the Interaction between Chelating Agents on their Fungitoxicity


THE role of chelation in the mechanism of action of 8-hydroxyquinoline (‘oxine’) against fungi has been reviewed by Horsfall1 and Hollingshead2. The increased bactericidal and fungicidal activity of this compound in the presence of Cu2+ has been ascribed to the rapid penetration of the cell wall by the highly lipophilic 1 : 2 copper: oxine complex3,4, which may dissociate within the cell to a more toxic substance or substances.

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    Horsfall, J. G., “Principles of Fungicidal Action”, Chap. 9 (Chronica Botanica Co., Waltham, Mass., 1956).

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    Hollingshead, R. G. W., “Oxine and its Derivatives”, Chap. 46 (Butterworth, London, 1956).

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    Dimond, A. E., and Horsfall, J. G., Science, 97, 144 (1943).

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BYRDE, R., WOODCOCK, D. Effect of the Interaction between Chelating Agents on their Fungitoxicity. Nature 179, 539 (1957) doi:10.1038/179539a0

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