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Enzymatic Synthesis of N-Glucuronic Acid Conjugates

Nature volume 179, pages 538–539 (1957)Cite this article

Abstract

RECENT investigations have shown that the formation of glucosiduronic acids can be catalysed by cell-free preparations of mammalian liver with uridine diphosphate glucuronic acid acting as the glucuronic acid donor1. These preparations have been found to synthesize ether- as well as ester-type glucuronic acid conjugates2. We wish to report the enzymatic synthesis of another type of conjugate in which glucuronic acid is linked to nitrogen.

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References

  1. (a) Dutton, G. J., and Storey, I. D. E., Biochem. J., 53, 37 (1953); (b) 57, 275 (1954). (c) Smith, E. E. B., and Mills, G. T., Biochim. Biophys. Acta, 13, 386 (1954). (d) Strominger, J. L., Kalckar, K. M., Axelrod, J., and Maxwell, E. S., J. Amer. Chem. Soc., 76, 6411 (1954). Isselbacher, K., and Axelrod, J., J. Amer. Chem. Soc., 77, 1070 (1955).

    Article  Google Scholar 

  2. Dutton, G. J., Biochem. J., 60, 19 (1955).

    Article  Google Scholar 

  3. Brodie, B. B., and Axelrod, J., J. Pharmacol. and Exp. Therap., 94, 22 (1948).

    CAS  Google Scholar 

  4. Boyland, E., and Manson, D., Biochem. J., 60, 2 (1955). Bushby, S. R. M., and Woiwod, A. J., Biochem. J., 63, 406 (1956).

    Google Scholar 

  5. Pollack, R. L., and Eades, jun., C. H., Science, 119, 510 (1954).

    Article  ADS  CAS  Google Scholar 

  6. Schneider, W. C., J. Biol. Chem., 176, 259 (1948).

    CAS  Google Scholar 

  7. Strominger, J. S., Maxwell, E. S., Axelrod, J., and Kalckar, H. M., J. Biol. Chem. (in the press).

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Authors and Affiliations

  1. National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

    JULIUS AXELROD & JOSEPH K. INSCOE

  2. National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

    GORDON M. TOMKINS

Authors
  1. JULIUS AXELROD
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  2. JOSEPH K. INSCOE
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  3. GORDON M. TOMKINS
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AXELROD, J., INSCOE, J. & TOMKINS, G. Enzymatic Synthesis of N-Glucuronic Acid Conjugates. Nature 179, 538–539 (1957). https://doi.org/10.1038/179538a0

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  • DOI: https://doi.org/10.1038/179538a0

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