Hyponitrite Reductase in Neurospora


THERE is much uncertainty in regard to the pathway of nitrite reduction in micro-organisms and in higher plants. Although nitrite and hydroxylamine reductases have been found in some bacteria1, Neurospora and in higher plants2,3, the immediate reduction product of nitrite has not been identified. Several workers4 have suggested that hyponitrite is the intermediate, but Taniguchi et al.1 have shown that hyponitrite was not reduced by crude extracts of a bacterium tolerant to halogens containing all the enzyme systems for the successive reduction of nitrate to ammonia. In the denitrification process, too, hyponitrite as well as nitramide have been postulated to be intermediates in nitrite reduction. Lees5, however, found that hyponitrite was not utilized by washed cells of Nitrosomonas.

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    Taniguchi, S., Mitsui, H., Toyoda, T., and Egami, F., J. Biochem. (Japan), 40, 175 (1952).

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    Virtanen, A. I., and Rautanen, N., in “The Enzymes”, edit. Sumner, J. B., and Myrback, K., 2, 1089 (Academic Press, New York, 1952).

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    Lees, H., “Biochemistry of Autotrophic Bacteria”, 49 (Butterworths Sci. Pub., London).

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MEDINA, A., NICHOLAS, D. Hyponitrite Reductase in Neurospora. Nature 179, 533–534 (1957) doi:10.1038/179533a0

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