Decrease of Phosphorus/Oxygen Ratios by Dinitrophenol in vivo


IN a paper by one of us1, it was reported that intraperitoneal administration of 2 : 4-dinitrophenol produces a high degree of uncoupling of oxidative phosphorylation in mitochondria from several rat tissues. There were histological changes in these tissues, which showed mitochondrial swelling and cloudy swelling. In the case of the liver, we have found that very shortly after treatment, fat droplets appear in the cells, followed later by glycogen. Similar changes were observed by Fonnesu and Severi2,3, who found also that cloudy swelling is characterized by decrease of phosphorus/oxygen ratios. In addition, treated rats showed increase of body temperature, a condition which has been referred by many authors to the decline of phosphorylation4,5.

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DIANZANI, M., DIANZANI MOR, M. Decrease of Phosphorus/Oxygen Ratios by Dinitrophenol in vivo. Nature 179, 532 (1957).

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