Oxytocic Effect of some d-Lysergic Acid cycloAlkylamides


ERGOMETRINE (d-lysergic acid L(+)-propanolamide-(2)) and methylergometrine (methylergobasine, d-lysergic acid (+)-butanolamide-(2) exhibit a pronounced oxytocic effect1. On the other hand, the oxytocic effect of d-lysergic acid diethylamide is very small2. It has been shown3 that the pharmacological properties of ergot alkaloids are profoundly changed by a relatively slight modification of the molecular structure. Saturation of the double bond in ring D of the molecule of ergotamine and alkaloids of the ergotoxine group causes a loss of the oxytocic effect and potentiation of the sympatholytic activity. Prolongation of the side-chain of ergometrine causes in the case of methylergometrine a potentiation of the oxytocic effect.

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    Rothlin, E., Schweiz. Med. Wschr., 76, 1254 (1946).

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    Semonský, M., Zikán, V., and Votava, Z., Chem. Listy (In the press); Coll. Czech. (in the press).

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VOTAVA, Z., PODVALOVÁ, I. & SEMONSKÝ, M. Oxytocic Effect of some d-Lysergic Acid cycloAlkylamides. Nature 179, 474–475 (1957). https://doi.org/10.1038/179474b0

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