Histochemical Evidence of Increased Activity of Hydrolytic Enzymes in the Cells of Old Animals

Abstract

HISTOCHEMICAL studies, mainly of dephosphorylating enzymes, have been made on sixteen different organs in young (three-months old) and old (three-years old) rats. Substrates used were glycerophosphate, œstrone phosphate, cortisone phosphate, pyridoxal phosphate, carbamyl phosphate and ethanolamine phosphate, and the pH used was 9.0. Evidence has been published1,2 (or has been obtained but not yet published) from this laboratory that these compounds are dephosphorylated probably by specific enzymes.

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References

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    Bourne, G. H., J. Physiol., 124, 410 (1954).

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    Bourne, G. H., Gerontologia (in the press).

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BOURNE, G. Histochemical Evidence of Increased Activity of Hydrolytic Enzymes in the Cells of Old Animals. Nature 179, 472 (1957) doi:10.1038/179472a0

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