Abstract
THE structure of polyadenylic acid can be expected to have some influence on the availability of polar groups, such as the primary amino-group of the adenine base, for binding of hydrogen ions. Titration and spectrophotometric studies of polyadenylic acid under a variety of conditions indicate that the primary amino-group in the adenine base is free in alkaline solutions, and probably combines in what appears to be a salt linkage with a neighbouring phosphate group of another nucleotide in acid solutions.
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References
Beers, jun., R. F., Biochem. J. (in the press).
Sevag, M. K., Biochem. Z., 273, 419 (1934).
Fraenkel-Conrat, H., Biochim. et Biophys. Acta, 15, 307 (1954).
Steiner, R. F., and Beers, jun., R. F. (to be published).
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BEERS, R., STEINER, R. Titration and Spectrophotometric Studies upon Polyadenylic Acid. Nature 179, 1076–1077 (1957). https://doi.org/10.1038/1791076b0
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DOI: https://doi.org/10.1038/1791076b0
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