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Glucuronic Acid, a Precursor of Ascorbic Acid in Aspergillus niger


THE isotopic work of Jackel, Mosbach, Burns and King1 with rats, and that of Sivarama Sastry and Sarma2 with plants, showed definitely that in both these species, glucose is the direct precursor of L-ascorbic acid. The studies of Horowitz and King3 and Isherwood, Chen and Mapson4 have established that in both cases glucuronic acid is an intermediate in the conversion of glucose to ascorbic acid, which takes place according to the sequence:

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SASTRY, K., SARMA, P. Glucuronic Acid, a Precursor of Ascorbic Acid in Aspergillus niger. Nature 179, 44–45 (1957).

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