Abstract
THE protection afforded by vitamin B12 against thyrotoxicosis in the rat was explained as due to a restoration in part of the uncoupling of oxidative phosphorylation caused by thyroxine1. Since it is known that osmotic damage to mitochondria could cause a diminution in oxidative phosphorylation2, the possibility was considered that in hyperthyroidism there may be an altered distribution of vitamin B12 in the cell fractions.
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References
Fatterpaker, P., Marfatia, U., and Sreenivasan, A., Nature, 176, 165 (1955).
Kielley, W. W., and Kielley, R. K., J. Biol. Chem., 191, 485 (1951). Dianzani, M. U., Biochim. Biophys. Acta, 14, 514 (1954).
Fatterpaker, P., Marfatia, U., and Sreenivasan, A., Nature, 167, 1067 (1951).
Schneider, W. C., and Hogeboom, G. H., J. Biol. Chem., 183, 123 (1950).
Rege, D. V., Ph.D. Thesis, University of Bombay (1953).
Dianzani, M. U., Biochim. Biophys. Acta, 17, 391 (1955). Glock, G. E., and Mclean, P., Biochem. J., 61, 400 (1955). Maley, G. F., and Lardy, H. A., J. Biol Chem., 215, 385 (1955).
Siekevitz, P., and Potter, V. R., J. Biol. Chem., 215, 221, 237 (1955).
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LAVATE, W., SREENIVASAN, A. Protective Action of Vitamin B12 in the Hyperthyroid Rat. Nature 178, 804–805 (1956). https://doi.org/10.1038/178804a0
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DOI: https://doi.org/10.1038/178804a0
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