Ammonia Production in the Collecting Ducts of Mammalian Kidneys


COMPARED with other parts of the nephron, the cells of the collecting ducts are morphologically conspicuous by the absence of any particular differentiation. This has led to the assumption that their function is exclusively mechanical, that is, to convey the urine from the distal part of the nephron to the renal pelvis. Physiologists have not been able to assign any active cellular function to this part of the nephron, though Glimstedt1 and Wirz2 presented convincing evidence for its importance in water reabsorption and we have suggested3 that back-diffusion of ammonia might occur in this segment. Both these functions are presumably of physicochemical nature and independent of cellular activity.

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  1. 1

    Glimstedt, G., Nord. Med., 12, 2924 (1941).

  2. 2

    Wirz, H., Hargity, B., and Kuhn, W., Helv. Physiol. Acta, 9, 196 (1951).

  3. 3

    Richterich-van Baerle, R., Goldstein, L., and Dearborn, Earl H., Science, 124, 74 (1956).

  4. 4

    Dickens, F., and Weil-Malherbe, H., Biochem. J., 30, 659 (1936).

  5. 5

    Weil, L., and Jennings, R. K., J. Biol. Chem., 139, 421 (1941).

  6. 6

    Wachstein, M., J. Histo. and Cytochem., 3, 246 (1955).

  7. 7

    Meister, A., Physiol. Rev., 36, 103 (1956).

  8. 8

    Richterich-van Baerle, R., Goldstein, L., and Dearborn, Earl H., Enzymologia (submitted for publication).

  9. 9

    Krebs, H. A., Deutsche Med. Wchnschr., 81, 4 (1956).

  10. 10

    Walker, A. M., Amer. J. Physiol., 131, 187 (1940).

  11. 11

    Albright, F., et al., Bull. Johns Hopkins Hosp., 66, 7 (1940).

  12. 12

    Baines, G. H., Barclay, J. A., and Cooke, W. T., Quart. J. Exp. Med., 14, 113 (1945).

  13. 13

    Montgomery, H., and Pierce, J. A., Amer. J. Physiol., 118, 144 (1937).

  14. 14

    Oliveira, H. L. de, Metabolism, 2, 37 (1953).

  15. 15

    Fanconi, G., Helv. Paediat. Acta, 1, 183 (1946).

  16. 16

    Lowe, C. U., Terrey, M., and MacLachlan, E. A., Amer. J. Dis. Child., 83, 164 (1952).

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