Fixation of Carbon Dioxide into the Carboxyl Carbon of Glycine


IT has been observed that carbon dioxide is a precursor to the carboxyl carbon of glycine in incubations with a hen-oviduct mince. Carbon 2 of the glycine is completely unlabelled when determined as the formaldehyde domed one complex obtained after ninhydrin degradation. Carboxyl-labelled acetate is also formed in this system from carbondioxide1. Acetate 1,2-14C, however, was found to be a poor precursor to glycine, although it was converted to glutamic acid much more efficiently than carbon dioxide.

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  1. 1

    Hendler, R. W., and Anfinsen, C. B., J. Biol. Chem., 209, 55 (1955).

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