Concentration of Thiocyanate labelled with Sulphur-35 in the Thyroid of the Hamster

Abstract

THIOCYANATES are known to inhibit the concentration of iodide by the thyroid. We have found that labelled thiocyanate is concentrated in the follicles of the hamster's thyroid. Adult hamsters were given 35S-thiocyanate (150 µc. with 100 µgm. of carrier) by intramuscular injection. The thyroid was removed 1 hr. later and dried from the frozen state at − 40° C. Contact autoradiographs were then made from sections of the tissue1. Patches of blackening were seen on the autoradiographs, corresponding to the areas of colloid in the section (Fig. 1). The density of the photographic grains over the centres of the follicles varied from 2.1 to 4.9 times the density over the centres of blood-vessels, the density over the smaller areas of colloid tending to be greater than that over the larger areas.

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References

  1. 1

    Doniach, I., and Logothetopoulos, J. H., J. Endocrinol., 13, 65 (1955).

  2. 2

    Pollard, F. H., and McOmie, J. F. W., “Chromatographic Methods of Inorganic Analysis” (Butterworths, London, 1953).

  3. 3

    Pitt-Rivers, R., and Trotter, W. R., Lancet, ii, 918 (1953).

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