Peroxide Formation in Bacteriological Media


IT has been observed that small inocula of Mycobacterium tuberculosis grow poorly in synthetic media unless certain additions (serum fractions, hæmoglobin, cobalt, charcoal) all of which are peroxide-destroying agents are made. Highly isoniazid-resistant strains of M. tuberculosis (which are much more sensitive to hydrogen peroxide than isoniazid-sensitive strains) show a greater demand for such peroxide destroyers, especially when manganese is present in the medium1. Consequently, it has been suggested that these media contain traces of peroxide, although this had not been confirmed chemically.

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