Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Peroxide Formation in Bacteriological Media

Abstract

IT has been observed that small inocula of Mycobacterium tuberculosis grow poorly in synthetic media unless certain additions (serum fractions, hæmoglobin, cobalt, charcoal) all of which are peroxide-destroying agents are made. Highly isoniazid-resistant strains of M. tuberculosis (which are much more sensitive to hydrogen peroxide than isoniazid-sensitive strains) show a greater demand for such peroxide destroyers, especially when manganese is present in the medium1. Consequently, it has been suggested that these media contain traces of peroxide, although this had not been confirmed chemically.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cohn, M. L., Oda, U., Kovitz, C., and Middlebrook, G., Amer. Rev. Tuberc., 70, 465 (1954).

    CAS  Google Scholar 

  2. Richardson, A., J. Chem. Soc., 1109 (1893).

  3. Dieudonne, A., Arbeiten a.d. Kaiserl. Gesundheitsamte, 9, 405, 437 (1894).

    Google Scholar 

  4. Winder, F., Amer. Rev. Tuberc., 73, 779 (1956).

    CAS  Google Scholar 

  5. O'Meara, R. A. Q., and Macsween, J. C., J. Path. Bact., 44, 225 (1937).

    Article  CAS  Google Scholar 

  6. Seigel, S. M., and Galston, A. W., Arch. Biochem. Biophys., 54, 102 (1955).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BARRY, V., CONALTY, M., DENNENY, J. et al. Peroxide Formation in Bacteriological Media. Nature 178, 596–597 (1956). https://doi.org/10.1038/178596a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/178596a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing