Carnosine Phosphate as Phosphate Donor in Muscular Contraction


CARNOSINE phosphate was first synthesized by Severin, Georgievskaya and Ivanov1 by a method very similar in detail to that for creatine phosphate2. They showed that this method yields as a rule a diphosphate, both phosphate bonds being high-energy; but that the one which is not on the imidazole ring is more labile. In the presence of muscle extract the latter is transferred to adenosine diphosphate.

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