Abstract
HYDROXYPYRUVATE is a metabolite which can arise from the biological oxidation of glycerate1, transamination of serine2, or decarboxylative condensation of glyoxylate3. In the presence of cocarboxylase, magnesium ions and transketolase, it yields ‘active’ (cocarboxylase-bound) glycolaldehyde, capable of forming a ketopentose 5-phosphate with D-glycer-aldehyde 3-phosphate4,5 or sedoheptulose 7-phosphate with D-ribose 5-phosphate5,6. Transketolase decarboxylates hydroxypyruvate only when a suitable acceptor aldehyde is present5 (acetaldehyde will not serve7) and does not decarboxylate pyruvate5,7. Crude yeast pyruvate carboxylase, on the other hand, has been stated not to decarboxylate hydroxypyruvate8.
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References
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DICKENS, F., WILLIAMSON, D. Formation of Erythulose from Hydroxypyruvate in the Presence of Yeast Carboxylase. Nature 178, 1349–1350 (1956). https://doi.org/10.1038/1781349b0
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DOI: https://doi.org/10.1038/1781349b0
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