Abstract
AT about the same time that we announced the existence of prehumulone1, the presence of a fourth lupulone in hops was suggested by Howard, Pollock and Tatchell2. The present communication gives chromatographic proof of the existence of such a substance, which we propose to call ‘prelupulone’. This chromatographic separation of the lupulone fraction of hops into its four components has been achieved by the technique described by us for the chromatography of the ‘humulone complex’1. This is shown in the elution pattern of Fig. 1, which was obtained on a silica gel column, 1.3 cm. × 123 cm., buffered at pH 10.55 and containing 25 per cent methanol. The four bands were named in accordance with present knowledge of humulone chemistry1,3.
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References
Verzele, M., Bull. Soc. Chim. Belg., No. 64, 70 (1955).
Howard, G. A., Pollock, J. R. A., and Tatchell, A. R., J. Chem. Soc., 174 (1955).
Rigby, F. L., and Bethune, J. L., J. Amer. Chem. Soc., 74, 6118 (1952).
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VERZELE, M. The Lupulone and isoHumulone Complex. Nature 177, 183 (1956). https://doi.org/10.1038/177183a0
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DOI: https://doi.org/10.1038/177183a0
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