Effect of Antibody on the Respiratory Rate of Trypanosoma vivax


THE West African N'Dama breed of cattle shows a remarkable tolerance to trypanosomiasis, as was demonstrated by Chandler1. In order to investigate the nature of this tolerance, it was necessary to develop a technique which would give a quantitative estimation of antibody titre. Methods employed in the study of bacteriological immunity are not generally applicable to the study of the immune response as it occurs in African trypanosomiases. Tests such as the mouse protection test employed by Fiennes2 in studying T. congolense infections do not readily give a quantitative estimate of antibody titre and are operative only when the trypanosomes survive in the host as a patent or latent infection.

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  1. 1

    Chandler, R. L., Ann. Trop. Med. Parasit., 46, 127 (1952).

  2. 2

    Fiennes, R. N. T.-W., Ann. Trop. Med. Parasit., 44, 42 (1950).

  3. 3

    Desowitz, R. S., and Watson, H. J. C., Ann. Trop. Med. Parasit., 46, 92 (1952); 74, 247 (1953).

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DESOWITZ, R. Effect of Antibody on the Respiratory Rate of Trypanosoma vivax . Nature 177, 132–133 (1956). https://doi.org/10.1038/177132b0

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