THERE is good evidence that the filamentous forms characteristic of many recently isolated strains of influenza A are infective units1; but their significance in relation to the process of influenza virus replication is by no means clear. It has been suggested that filaments represent the initial form in which the infective phase of the virus is produced, spheres being formed secondarily2. Others have suggested that the filament is a by-product, as it were, of the process by which new infective particles are produced at the free surface of the allantoic cell3.
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Flewett, T. H., and Challice, C. E., J. Gen. Microbiol., 5, 279 (1951).
Hotz, G., and Schafer, W., Z. Naturforsch., 10, 1 (1955).
Chu, C. M., Dawson, I. M., and Elford, W. J., Lancet, i, 602 (1949).
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Journal of General Virology (2019)
Medical Hypotheses (2006)