Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Pharmacological Action of Rauwolscine


RAUWOLSCINE (kindly supplied by Mrs. A. Chatterjee, University College of Science and Technology, Calcutta), an alkaloid of Rauwolfia canescens Linn.1, has been found to be a potent adrenolytic compound2,3. It has further been shown to be α-yohimbine4. Yohimbine is an adrenergic blocking alkaloid; but it produces certain other effects, such as stimulation of the central nervous system, local anæsthesia and vague aphrodisiac activity5, which have precluded its use in clinical practice. No detailed report has appeared so far of any investigation of these properties; we have therefore examined these pharmacological actions of rauwolscine with the following results.


  1. 1

    Chatterjee, A., J. Ind. Chem. Soc., 18, 33, 485 (1941).

    Google Scholar 

  2. 2

    Chakravarti, M. D., Science and Culture, 8, 8 (1942).

    Google Scholar 

  3. 3

    Mukerjee, J. N., and Sen, P. B., Ind. J. Physiol. and Allied Sci., 7, 57, 109 and 148 (1953).

    Google Scholar 

  4. 4

    Chatterjee, A., Bose, A. K., and Pakrashi, S., Chem. and Indust., 491 (1954).

  5. 5

    Sollmann, T., “A Manual of Pharmacology”, 278 (W. B. Saunders Co., 1949).

    Google Scholar 

  6. 6

    Bülbring, E., and Wajda, J. Pharmacol, 85, 78 (1945).

    Google Scholar 

  7. 7

    Stone, C. A., and Earl, R. L., J. Pharmacol., 106, 226 (1952).

    CAS  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

KOHLI, J., DE, N. Pharmacological Action of Rauwolscine. Nature 177, 1182 (1956).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing