IT is now a commonplace that, in culture, resistant organisms may be already present before there has been any contact between them and an antibiotic1. I demonstrated1a that this was true even in young cultures derived from single cells.
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(a) Hughes, W. H., J. Gen. Microbiol., 6, 175 (1952). (b) Eagle, H., Fleischmann, R., and Levy, M., J. Bact., 63, 623 (1952). (c) Collard, P., Riass. Commun. VI Cong. int. Microbiol., 1, 155 (1953). (d) Mayr-Harting, A., J. Gen. Microbiol., 13, 9 (1955).
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HUGHES, W. Bacterial Variation to Sensitivity : an Example of Individuality in Micro-organisms. Nature 177, 1132–1133 (1956). https://doi.org/10.1038/1771132a0