IT is generally accepted that the effect of clinical doses of reserpine on the circulation is central in origin and that such doses have no peripheral effect of any significance. It has recently been shown that reserpine and serotonin have similar effects on the central nervous system, and that relatively large doses of reserpine in dogs markedly increase the urinary secretion of a metabolite of serotonin1. It has therefore been suggested that certain actions of reserpine are mediated through the liberation of serotonin from the intestine2.
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Shore, P. A., Silver, S. L., and Brodie, B. B., Science, 122, 284 (1955).
Pletscher, A., Shore, P. A., and Brodie, B. B., Science, 122, 374 (1955).
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NAESS, K., SCHANCHE, S. Effect of Reserpine on Serotonin in Rabbit Serum. Nature 177, 1130–1131 (1956). https://doi.org/10.1038/1771130b0
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