Abstract
IT is generally believed that the action of pitressin, and more specifically, antidiuretic hormone, is entirely referable to its effects on the kidney. Although an extrarenal site of action has been suggested, the evidence has not been convincing1. Our recent studies in the rat suggested that pitressin might have an extrarenal action in this mammal2. This would agree with the findings in other vertebrate classes3.
References
Smith, H. W., “The Kidney: Structure and Function in Health and Disease”, 263 et seq. (Oxf. Univ. Press, New York, 1951).
Friedman, S. M., Webber, W. A., and Friedman, C. L., Canad. J. Biochem. and Physiol., 34, 475 (1956).
Heller, H., Experientia, 6, 368 (1950).
Ledingham, J. M., Clin. Sci., 12, 337 (1953).
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FRIEDMAN, S., FRIEDMAN, C. & NAKASHIMA, M. An Extrarenal Effect of Pitressin. Nature 177, 1079 (1956). https://doi.org/10.1038/1771079a0
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DOI: https://doi.org/10.1038/1771079a0
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