THE optimal bone graft is one which is most readily : (1) accepted with least reaction, (2) incorporated in callus formation, (3) vascularized with subsequent mineralization, and (4) absorbed (remodelled) by the host. Assuming that the constituents of bone which cause failure are contained in the organic fraction (antigens, fats, mucopolysaccharides, etc.), its removal would allow host acceptance of foreign bone. The remaining inorganic matrix might then be suitable for surgical prosthesis in situations where ‘banked’ bone is now required. The use of such inorganic bone transplants would, in addition, alleviate the present problems of procuring, storing and supplying whole bone.
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LOSEE, F., HURLEY, L. Bone treated with Ethylenediamine as a Successful Foundation Material in Cross-Species Bone Grafts. Nature 177, 1032–1033 (1956). https://doi.org/10.1038/1771032a0
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