Abstract
IN 1954, Lux1 investigated the possibility that potent inhibitors of Eimeria tenella might be found among compounds, other than sulphonamides, which interfered with the p-aminobenzoic acid–folic acid metabolic sequence. Lux found that a group of 2,4-diamino-pyrimidines possessed anticoccidial activity, one of the most active of the series being 2,4-diamino-5, p-chlorophenyl, 6-ethyl pyrimidine (‘Pyrimethamine’, ‘Daraprim’). He noted, furthermore, that this compound, when used in combination with certain sulphonamides, had a marked synergistic effect.
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References
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JOYNER, L., KENDALL, S. Synergism in the Chemotherapy of Eimeria tenella. Nature 176, 975 (1955). https://doi.org/10.1038/176975a0
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DOI: https://doi.org/10.1038/176975a0
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