Abstract
THE chemical structure of the antibiotic peptide gramicidin S has been established as cyclo-(-L-Val-L-Orn-L-Leu-D-Phe-L-Pro)21. In the attempt to elucidate the relation between its chemical structure and the antibacterial activity, a number of related di-, tri-, penta- and deca-peptides have been synthesized, and their antibacterial activity tested2. These synthetic peptides contain some or all of the five amino-acids present in gramicidin S in the proper sequence. Appreciable antibacterial activity was exhibited only by the linear decapeptide.
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References
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KATCHALSKI, E., BERGER, A., BICHOWSKY-SLOMNICKI, L. et al. Antibiotically Active Amino-Acid Copolymers related to Gramicidin S. Nature 176, 118–119 (1955). https://doi.org/10.1038/176118a0
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DOI: https://doi.org/10.1038/176118a0
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