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Effect of Deoxycorticosterone on the Reticulo-Endothelial System


THE reticulo-endothelial system is known to be an important defence mechanism against malignant growths in general1. Nicol, Helmy and Abou-Zikry2 showed that œstrogens, especially in combination with orchidectomy, stimulate the reticulo-endothelial macrophages in the liver, spleen and lymph nodes and appear to lead to mobilization of the macrophages in these organs. It is probable that such stimulation increases the general defence of the body against tumour growth.

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    Kavetzki, R. E., and Diadjuscha, G. F., J. Med. Ukrain., 7, 837 (1937). Stern, K., J. Lab. Clin. Med., 26, 809 (1941).

  2. 2

    Nicol, T., Helmy, I. D., and Abou-Zikry, A., Brit. J. Surg., 40, 166 (1952).

  3. 3

    Nicol, T., and Snell, R. S., Nature, 174, 554 (1954).

  4. 4

    Pearson, O. D., Eliel, L. P., Rawson, R. W., Dobriner, K., and Rhoads, C. P., Cancer, 2, 943 (1949). Pearson, O. D., Eliel, L. P., and Talbot, jun., T. R., Bull. New York Acad. Med., 26, 235 (1950).

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    Frada, G., Presse Méd., 58, 78 (1950).

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