Letter | Published:

Tumours induced in Rats with 4′-Fluoro-4-Aminodiphenyl

Naturevolume 175page1131 (1955) | Download Citation



WE have made the following suggestions to explain the incidence and location of the tumours produced in rats with 4-aminodiphenyl and some of its nuclear methylated derivatives1. First, that in each instance the effective carcinogen is the corresponding ortho-hydroxy amine, formed in the liver and excreted in the bile; secondly, that 4-aminodiphenyl itself is largely metabolized to the 4′-hydroxy derivative and that little of the ortho-hydroxy amine, 3-hydroxy-4-aminodiphenyl, is formed; and finally, that in the metabolism of the more actively carcinogenic derivatives of 4-aminodiphenyl containing a methyl substituent in the 3 position, relatively more of the corresponding ortho-hydroxy amines are produced.

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  1. 1

    Walpole, A. L., Williams, M. H. C., and Roberts, D. C., Brit. J. Indust. Med., 9, 255 (1952).

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  1. Imperial Chemical Industries, Ltd., Hexagon House, Manchester, 9

    • J. A. HENDRY
    • , J. J. MATTHEWS
    • , A. L. WALPOLE
    •  & M. H. C. WILLIAMS


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