Letter | Published:

Actively Acquired Tolerance to a Mouse Tumour

Naturevolume 175pages10871088 (1955) | Download Citation



THE 6C3HED lymphosarcoma1 is an ascites tumour of mice, apparently of uniform antigenic properties, containing a near-diploid mode of chromosomes2. It is invariably lethal to C3H mice and to F 1 hybrids between the original strain and A or DBA mice. The tumour consistently regresses in mice of other strains. Since Billingham, Brent and Medawar3 have recently demonstrated that mice can be rendered susceptible to skin homografts by the injection of embryos in utero with donor-strain tissues, the same method has been applied to the abrogation of resistance of a strain of Swiss mice to the 6C3HED tumour.

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  1. 1

    Gardner, W. U., Kirschbaum, A., and Strong, L. C., Arch. Path., 29, 1 (1940).

  2. 2

    Levan, A., and Hauschka, T. S., J. Nat. Cancer Inst., 14, 1 (1953).

  3. 3

    Billingham, R. E., Brent, L., and Medawar, P. B., Nature, 172, 603 (1953).

  4. 4

    Koprowska, I., and Koprowski, H., Cancer Res., 13, 651 (1953).

  5. 5

    Koprowska, I., and Koprowski, H., J. Nat. Cancer Inst., 14, 627 (1953).

  6. 6

    Billingham, R. E., Brent, L., and Medawar, P. B., Ann. N.Y. Acad. Sci., 59, 409 (1955).

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  1. Viral and Rickettsial Section, Research Division, American Cyanamid Co., Pearl River, N.Y.



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