Letter | Published:

Intracellular Distribution of Xanthine Oxidase in the Rat Liver

Naturevolume 175page1087 (1955) | Download Citation

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Abstract

THE separation of cytoplasmic particles into fractions by differential centrifugation has been extensively used for the study of the distribution of intracellular cell constituents. Some enzymes of oxidative metabolism have been shown to be localized chiefly in the fraction of the liver containing large particles (mitochondria)1. During the course of an investigation of the xanthine oxidase of the rat liver, we have studied the intracellular distribution of this enzyme, since there seem to be no data in tho literature.

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References

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    Schneider, W. C., and Hogeboom, G. H., Cancer Res., 11, 1 (1951).

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    Villela, G. G., and Mitidieri, E., Nature [175, 208 (1955)].

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    Villela, G. G., Rev. Bras. Biol., 1, 455 (1954).

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    Hogeboom, G. H., Schneider, W. C., and Pallade, G. E., J. Biol. Chem., 172, 619 (1948).

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    Lanni, F., Dillon, M. L., and Beard, J. N., Proc. Soc. Exp. Biol. Med., 74, 4 (1950).

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    Schein, A. H., Podber, E., and Novikoff, A. B., Fed. Proc., 9, 224 (1950).

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    Richert, D. A., Vanderlinde, R., and Westerfeld, W. W., J. Biol. Chem., 186, 261 (1950).

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Affiliations

  1. Biochemical Laboratory, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil

    • GILBERTO G. VILLELA
    • , EMILIO MITIDIERI
    •  & OTTÍLIA R. AFFONSO

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https://doi.org/10.1038/1751087a0

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