Abstract
THE urinary substance referred to as B in a previous communication1 has now been isolated in pure form. It can be shown to be p-phenetidine by its infra-red and ultra-violet spectra, the melting point of a picrate (176–180° C.) and lack of depression of melting point in a mixture with authentic p-phenetidine picrate (179–181° C). It is present in urine as a labile acidic substance which can be precipitated by lead acetate and purified by paper chromatography from butanol–acetic acid (R F about 0.5). The precursor seems to be a conjugate with sulphuric acid. About 2–3 per cent of administered phenacetine is excreted in this form.
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References
Špaček, M., Nature, 172, 204 (1953).
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ŠPAČEK, M. Phenetidine in Urine. Nature 174, 933–934 (1954). https://doi.org/10.1038/174933b0
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DOI: https://doi.org/10.1038/174933b0
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