Abstract
PEACOCK1 induced hepatomas in seven of seventeen mice surviving subcutaneous injection of oil orange E (1-benzeneazo-2-naphthol) for more than fourteen months. This substance was then in use as a food dye. Clayson2 has since suggested that it might be active by virtue of its in vivo reduction to 1-amino-2-naphthol. If this be so, it was thought that other compounds capable of being reduced to this amino-haphthol might be carcinogenic.
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References
Peacock, P. R., Ann. Rep. Brit. Empire Cancer Campaign, 26, 198 (1948).
Clayson, D. B., Brit. J. Cancer, 7, 460 (1953).
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BONSER, G., CLAYSON, D. & JULL, J. Induction of Tumours with 1-(2-Tolylazo)-2-naphthol (Oil Orange TX). Nature 174, 879–880 (1954). https://doi.org/10.1038/174879b0
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DOI: https://doi.org/10.1038/174879b0
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